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These effects are usually most pronounced when starting treatment or increasing the dose
23 This need for injection can limit patient use and may also restrict the possibility of combining these drugs in fixed-dose treatments with other therapies for cardio-metabolic conditions
Animal studies use controlled purity, defined dosing, and monitoring that home use cannot replicate, and they still do not answer questions about long-term human exposure, immunogenicity, or rare serious events
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Further longitudinal analyses in initially non-depressed subjects are needed to properly disentangle these two mutually non-exclusive scenarios
Larger randomized controlled trials of GFCF diets are currently underway
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