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Left panel : Low-dose IV ACh primarily activates endothelial M3 muscarinic receptors, stimulating nitric oxide (NO) release and vascular smooth muscle relaxation, resulting in arterial vasodilation and reduced blood pressure

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In parallel, retrograde signaling originating from chloroplasts under high light conditions, together with abscisic acid (ABA)-dependent pathways, exemplifies how ROS link environmental cues to nuclear gene regulation (Mittler et al

J Egypt Soc Nephrol Transplant