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496 Besides the above drugs, structural and functional dysbiosis of intestinal microbiome are induced in obese rodents, 497,498 and they may cause IR and systemic inflammation

Hyperglycemia, insulin resistance, oxidative stress, advanced glycation end products, calcium dysregulation, and protein kinase C activation all converge to impair platelet mitochondrial function, leading to increased reactive oxygen species, altered bioenergetics, and defective mitophagy

e , Representative iNap1 fluorescence images of shCtrl and shTET1/2/3 H1299 cells with or without glucose starvation for 2.5 h

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