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Post-injection symptoms that might suggest incorrect administration include: Increased pain or soreness lasting several hours or days beyond typical injection site discomfort Deeper aching sensation in the injection area, particularly with movement of the affected limb Bruising at the injection site (though this can occur with proper technique as well) Technique factors that increase the risk of injecting too deeply include: Using a needle that is too long for your body composition Failing to pinch the skin adequately before injection (especially important for lean individuals) Injecting at an incorrect angle Injecting into areas with minimal subcutaneous fat If you consistently experience unusual discomfort or have concerns about your injection technique, contact your healthcare provider or diabetes educator

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[52] gave diet-induced obesity (DIO) mice daily GLP-1R/Gcg receptor (GcgR) double agonist (cotadutide), Lira, Gcg agonist (g1437), and Lira+g1437 respectively