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In the STEP 1 trial, semaglutide 2.4mg produced an average loss of 14.9% of body weight over 68 weeks, compared to just 2.4% on placebo
The starting doses of these medications are different
Am.J Kidney Dis 1999;34(4):678-687
Nutrition and Exercise Interventions to Improve Body Composition for Persons With Overweight or Obesity Near Retirement Age: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials
2022 Mar 25;23(7):3607
Other Affordable GLP-1 Options Available Without Insurance Beyond semaglutide, PlexusDx offers compounded tirzepatide (a dual GIP/GLP-1 receptor agonist) at $289/mo month-to-month, or from $249/mo on the 6-month plan, oral formulations of both medications, and the GLP-Squared dual-compound injection at $289/mo (or $249/mo on the 3-month plan)
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