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Las guas actuales de la Asociacin Americana de Diabetes (ADA) no identifican la tolerancia como una limitacin clnica principal para esta clase de medicamentos, aunque reconocen la necesidad de ms investigacin sobre sus efectos a muy largo plazo

This product should not be used as a substitute for a varied diet and healthy lifestyle

But the primary concern is the risk of ochronosis, a rare but challenging condition where long-term overuse paradoxically causes darkening of the skin, says Francesa Lewis, MD, a board-certified dermatologist in Delray Beach, Florida

And instead of hitting a plateau, which is common for existing drugs, they kept losing pounds

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Different routes of administration can lead to varying adverse reaction outcomes