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2 Ferroptosis 2.1 The key role of iron metabolism and iron overload in triggering ferroptosis Iron is an essential trace element that participates in fundamental physiological processes such as oxygen transport, energy metabolism, immune defense, and DNA synthesis

Research investigations reveal that senescent cells contribute to fibrosis through SASP-mediated inflammation, and their elimination can reduce fibrotic progression, providing researchers with tools for studying senescence contributions to fibrotic diseases and developing interventions for fibrosis research models

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Adverse effects of high-dose vitamin C

Summary: In Phase 2 clinical trials, retatrutide was typically initiated at 2 mg once weekly via subcutaneous injection, with gradual dose escalation over several months under close medical supervision