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Because they are supplements rather than prescription medications, systemic side effects are less defined, but the lack of clinical testing means overall safety remains uncertain

Tirzepatide (Zepbound) Clinical trial data cited by multiple sources, including NBC News, showed average weight loss of approximately 21 to 22.5 percent at the highest dose after 72 weeks, compared with about 3 percent for placebo

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However, several clinical studies have shown that GLP-1 intervention did not improve hepatic steatosis in NAFLD patients 18,19

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