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At therapeutic IV concentrations, it modulates NMDA receptors in the brain, which reduces the calcium influx that drives migraine aura and cortical spreading depression

Lin X, Tascilar M, Lee WH, Vles WJ, Lee BH, Veeraswamy R, Asgari K, Freije D, van Rees B, Gage WR, Bova GS, Isaacs WB, Brooks JD, DeWeese TL, De Marzo AM and Nelson WG

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To view or add a comment, sign in Ahead of the July 2026 Pharmacy Compounding Advisory Committee meeting, the FDA has released its scientific briefing documents

Treatment durations can range from a few weeks to several months, depending on the desired results

Further long-term clinical trials may be necessary to provide potential information in this aspect