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There are two 2HG enantiomers: D-2-hydroxyglutarate (D2HG) and L-2-hydroxyglutarate (L2HG), with the former predominantly generated from IDH1 mutants and PHGDH while L2HG is primarily generated from the promiscuous activity of LDHA and MDH1/2 under hypoxic or acidic conditions and converted back to 2OG by L2HGDH
in both approaches, cell viability was not affected in the present study
When performed in a licensed medical environment with proper screening, glutathione IV therapy is generally considered safe for suitable candidates
Z., Stemmler, T
doi: 10.1007/s10482-016-0737-y 71 JoshiS.McMackenM.Kalantar-ZadehK
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