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However, the temporal reduction of MACE events in people with type 2 diabetes treated with GLP-1RA takes longer, becoming evident from 12 to 18 months from trial initiation [115, 116]
study and the present study investigated astrocyte reactivity by GFAP staining, and we did not observe the decrease of GFAP staining seen in the Li et al
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"Once-Weekly Semaglutide in Adults with Overweight or Obesity." NEJM 2021 (STEP 1 trial) Rubino D, et al
Critically, the reduction in nauseating or emetic responses induced by GIPR agonism does not limit the short term (72h) weight loss in any preclinical model (69)
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