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Quick Answer: Zepbound may cause emotional changes in some patients, and the FDA label includes warnings to monitor for depression and suicidal thoughts, though clinical trials have not established a definitive causal relationship

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Hydration matters too: dehydration can exacerbate fatigue during the day and paradoxically trigger wakefulness at night as your body tries to conserve water

Its phenomenal, says Michael Krashes, a diabetes and obesity investigator at the National Institutes of Health