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Naltrexone extended-release plus bupropion extended-release for treatment of obesity In 2014, the FDA approved Contrave (naltrexone-bupropion) and Saxenda (liraglutide) for long-term obesity treatment

Dehydration risk typically decreases after a few weeks as gastrointestinal side effects subside for the majority of patients

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The timeline below explains what some patients report during the first four weeks, followed by months 2 through 12

If you struggle with alcohol dependence, please seek professional help through established treatment channels

The 'best' depends on your tolerance for newer compounds versus proven track records