These findings hint that GLP-1R-based therapeutics may engage epigenetic mechanisms, tentatively explaining their broad efficacy across multiple disorders
In pre-specified analyses for time to first occurrence of MACE, there were 44 MACE-5 (all-cause death, heart attack, stroke, heart failure event, or coronary revascularization ) events observed in participants randomized to retatrutide (pooled 9 mg and 12 mg) and 52 events observed in those randomized to placebo, resulting in a hazard ratio of 0.82 (95.0% CI: 0.55 to 1.22)
In a second treatment scenario, we assume that the diabetes prevention results from the clinical trial persist for the remainder of patients lives
valid until 4 August 2026 at 9.30 am
After 1 year of semaglutide treatment, in those with a history of metabolic surgery, %WL was significantly higher in patients who underwent RYGB (but not SG) compared with those with no MBS history
Beirowski, B