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The 90-day timeline reflects the tested window for peptide integrity under ideal refrigeration
Tirzepatide is injected subcutaneously
Sitagliptin is an inhibitor of dipeptidyl peptidase-4 (DPP4, also known as CD26), which is clinically used for DM treatment
PlexusDx recommends establishing a systematic rotation plan: inject to the right thigh one week, then alternate to the left thigh the following week, and rotate within each thigh between the outer and front surfaces
So it cannot prove from this trial alone that retatrutide is better than existing treatments
Weeks 1 through 4: 2 mg once weekly Weeks 5 through 8: 4 mg once weekly Weeks 9 through 12: 8 mg once weekly Weeks 13 and beyond: 8 to 12 mg once weekly (based on response and tolerance) This protocol reaches the therapeutic range in approximately 8 weeks
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