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The authors acknowledge the Department of Pharmaceuticals, Government of India, New Delhi for financial support under 4244 scheme for promotion of Research and Innovation in Pharma Med-Tech (PRIP)

VPA significantly increased the expression levels of antioxidant genes GSTA2, GSTA4, GSTM3 , and GPX2

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Management If B Deficiency Is Confirmed Oral cyanocobalamin: 10002000 g daily or IM hydroxocobalamin: Loading: 1 mg weekly for 46 weeks Maintenance: 1 mg every 23 months Metformin should usually be continued Supplement B rather than stopping metformin 7