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Compounded glucagon-like peptide-1 receptor agonists (GLP-1RA) products are not identical to the TGA-approved products Ozempic (semaglutide) or Mounjaro (tirazapetide)
Recent studies suggest that treatment with semaglutide (GLP-1RA) in combination with firsocostat (ACC-a inhibitor) and/or cilofexor (nonsteroidal FXR agonist) can further improve hepatic steatosis and thus NAFLD compared with semaglutide alone in exploratory efficacy analyses [113]
The authors emphasise that, as an observational analysis, the study cannot establish a causal relationship between hormone therapy and enhanced weight loss
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Some patients lose 5+ lb in month 1, mostly driven by water weight and dietary baseline drop
Weeks six and seven were the toughest stretch
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