[148] have highlighted the neuropsychiatric dimensions of GLP-1 RAs, including their potential relevance for relapse vulnerability and cognitive-affective regulation after pharmacotherapy discontinuation
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In a randomized trial of semaglutide 2.4 mg vs placebo for 1 year, 529 participants with HFpEF with a BMI of 30 kg/m2, there was a very large reduction in symptoms, improvement in exercise function in the GLP-1 drug assigned group
Mounjaro tirzepatide is also effective as a weight loss medication
Individuals interested in GLP-1s should discuss with their healthcare provider to determine whether or not they may be beneficial to you, depending on your health concerns and goals
The trials, NCT06588296 (TOGETHER-PsA) and NCT06864026 (TOGETHER AMPLIFY-PsA), assessed ixekizumab with and without tirzepatide