Also, the previous literature dominated by older trials from specific regions (mostly Europe), which may limit generalizability to other settings
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Treatment Augmentation After adjustment, approximately one-third of DPP4i users added a new glucose-lowering drug class compared with approximately one-fifth of semaglutide users during the 2-year follow-up (31.8% vs 19.3%, respectively
Both disproportionality analyses confirmed this heightened risk: ROR analysis showed a statistically significant association (ROR = 1.81, 95% CI 1.622.03), while BCPNN yielded an information component of IC = 0.85 (IC025 = 0.69), both indicating substantially greater renal impairment risks in this older population treated with the combination therapy
The safety and efficacy of N-acetylcysteine as an augmentation in the treatment of obsessive-compulsive disorder in adults: a systematic review and meta-analysis of randomized clinical trials