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Osteoporosis was experimentally induced using a high-fat diet with streptozotocin in two studies, ovariectomy in two studies, and dexamethasone administration in one study

This suggests that DIV-1 may act upstream of GLD-3 and NOS-3 pathways (see Fig

Treatment with FOXO4-DRI normalized these metabolic indicators, effectively restoring kidney filtering capacity to levels approaching those of young animals

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