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Lancet 1987;2:1300-4.ArticlePubMed 5
However, the physiological half-life of GLP-1 in circulation is very short (less than 2 min), which can be attributed to both rapid proteolytic cleavage of the amide bond of alanine at position 8 (Ala8) in the N-terminus by ubiquitous dipeptidyl peptidase IV (DPP-IV), which results in the removal of the two N-terminal amino acids leading to the formation of a truncated inactive form 10,11 and clearance by the kidney as well
Dose Recommendations: Patients typically start on a low dose of semaglutide, gradually increasing as the body adjusts to the treatment
Many people combine it with structured nutrition plans or fat burner supplements for a more comprehensive approach
Work With a Registered Dietitian at Sparkman Nutrition If youre taking Ozempic, Wegovy, Mounjaro, Zepbound, or another GLP-1 medication , you dont have to navigate nutrition alone
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