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Most of these biomarkers are modulated by glutathione and its precursors at the mitochondrial level

And BMI also doesnt factor in body fat distribution or consider other health conditions

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When combined with the exclusion of patients with either acute or chronic pancreatitis from prior clinical trials, this observation aligns with the caution raised by the American Diabetes Association to avoid use of GLP-1RAs for patients with any history of acute or chronic pancreatitis 27

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That does not mean one is universally better