Therefore, these studies showed advantage of DPP-4 inhibition over sulfonylureas as add-on to metformin in regard both to lower risk of hypoglycemia and no weight gain
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Defective mitochondrial DNA homeostasis in the substantia nigra in Parkinson disease
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This "metabolic buffering" role helps maintain the CoA/acyl-CoA ratio essential for TCA cycle function [1]
Interestingly, gut-selective doses of sitagliptin retained the ability to improve glucose tolerance in mice with genetic ablation of DPP-4 from endothelial cells, albeit only in animals fed a chow diet and not those receiving a high-fat diet