Recent studies looking at the telomeric proteome during replication observed high levels of histone protein H1 at telomeres during replication (Lin et al 2021), and cells that had H1 depleted through knockout experiments are sensitive to DNA damage and double strand breaks (Murga et al 2007)
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A recent study found that the highest driver of a physicians choice of treatment was reduction in percentage of body surface area affected, overall perception of fficacy, and maintenance of response
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However, TRT is not a relationship treatment