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The corresponding pharmacokinetic parameters are listed as follows: T max = 0.167 h, C max = 155 11.8 ng Eq./ml, AUC 0t = 4945 417 h ng Eq./ml, AUC 0 = 12956 2074 hng Eq./ml, average residence time (MRT 0-t ) of plasma total radioactivity = 33.2 1.03 h, and t 1/2 = 102 h (Table 9)
In-vitro receptor activation assays demonstrated that the molecule interacts with GLP-1 and GIP receptors
The Journal of Pediatrics 236 , 137-147.e13 (2021)
Diabetic kidney lesions of GIPRdn transgenic mice: podocyte hypertrophy and thickening of the GBM precede glomerular hypertrophy and glomerulosclerosis
