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HDAC inhibition by SX-275 restores expression of silenced leukemia-associated transcription factors Nur77 and Nor1 and of key pro-apoptotic proteins in AML
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However, in these trials, the drug was not proven effective at significantly reducing weight of the obese individuals, supported by robust statistical analysis.
Figure 6 CCK-8 assay and colony formation analysis showed that overexpression of RRM2 promoted the proliferation of TPC-1 cell, whereas inhibition of RRM2 expression reversed this process ( Figures 6C, D )
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