Liang LP, Patel M
Besides, peripheral injection of imatinib, a -secretase inhibitor that does not cross the BBB, can lead to decreased plasma and brain A protein levels [42, 43]
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Pickart stated that GHK-Cu has a favorable safety profile, highlighting that there is no indication that it causes side effects in test subjects [2]: The molecule is very safe and no issues have ever arisen during its use as a skin cosmetic or in human wound healing studies. In a 2018 review based on new genetic data, he reiterated that all biological actions associated with GHK appear to be health positive. He pointed to over four decades of GHK research encompassing cell, tissue, and animal studies, also noting the peptides inclusion in commercial anti-aging and cosmetic products such as creams, liposomes, and dermal patches [1]
Clinical implications include low toxicity, maintenance of the normal function of the cells, and high patient quality of life [139, 140]