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A p-value of less than 0.05 was set as the threshold for clinical significance

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consider ECG if clinically indicated Nutritional status : Assess current dietary intake, eating patterns, and screen for disordered eating behaviours Mental health evaluation : Screen for depression, anxiety, or other psychiatric comorbidities that may affect treatment adherence or outcomes Weight and metabolic parameters : Record baseline weight, BMI, waist circumference, and relevant blood tests (HbA1c, lipid profile, renal function) Pregnancy status : Exclude pregnancy and discuss contraception requirements (Wegovy is contraindicated in pregnancy) Treatment should begin with a dose of 0.25 mg once weekly, increasing every 4 weeks (0.5 mg, 1.0 mg, 1.7 mg) to reach the maintenance dose of 2.4 mg if tolerated

Allow the medication to reach room temperature before injection, ensure skin is completely dry after alcohol preparation, rotate injection sites systematically, and follow device-specific instructions for proper technique including appropriate hold times after injection

That said, if you have kidney or liver disease or are at risk of either, creatine may present a hazard