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If levels don't respond to standard supplementation, investigate possible MTHFR polymorphisms, malabsorption conditions like celiac or Crohn's disease, or potential medication interactions

In addition, there is a likely analogy (see for review i.e., (Seiwerth et al., 2018)) with the attenuated fibrosis and scar formation in other tissues (i.e., the skin, muscle, tendon, and ligament) (Mikus et al., 2001

Nussinov R, Yavuz BR, Demirel HC, Arici MK, Jang H, Tuncbag N (2024b) Review: Cancer and neurodevelopmental disorders: multi-scale reasoning and computational guide

Peptides occupy a central position in AD pathobiology: pathogenic species such as A oligomers and tau-derived fragments drive synaptic failure, mitochondrial dysfunction, and neuroinflammation, whereas several endogenous neuropeptides exert compensatory neuroprotective, trophic, or homeostatic effects

The result was an epidemic of vitamin B12 deficiency, especially in the northern climates of Europe, Russia, and North America

Cachexia Sarcopenia Muscle 14 (3), 13651380