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We then used Delongs test based on area under the curve (AUC) to assess whether other additional clinically meaningful factors improved the predicted probability of the simple screening index, then used net reclassification index (NRI) to evaluate strength of model improvement
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Effects on Mood and Anxiety Large clinical trials of semaglutide at a 2.4 mg dose found no consistent rise in depression or anxiety, even when assessed with tools like the PHQ-9 and Columbia-Suicide Severity Rating Scale
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