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Regarding collateral effects, the most commonly reported were gastrointestinal-related (diarrhea, nausea, vomiting, constipation) mainly occurring during the dose escalation period

Dietary intake of fiber and decreased risk of cancers of the colon and rectum: evidence from the combined analysis of 13 case-control studies

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And so, um, I guess what would be interesting is for you, what are a few early like because I think a lot of the times you end up with people after theyve sort of ignored something for a while or theyve maybe necessarily kicked the can down the road, then they tried to go see some other people and it progressed to a point where like then you get called in