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Am J Physiol Gastrointest Liver Physiol
Diarrhea, nausea, and vomiting may cause a loss of fluids (dehydration) which may cause kidney problems
Neurological Effects Investigated for its role in neuroprotection and cognitive health
Although the SAVOR and EXAMINE studies were delineated to verify cardiovascular safety of two DPP-4i, namely saxagliptin and alogliptin, respectively, both are considered to be the first controlled clinical trials to address the effect of GLP-1 system on CVD
Retatrutide remains investigational with no MHRA or EMA marketing authorisation
And our current thinking about obesity, and one of the components of the disease of obesity, is that some individuals although they all have GLP-1 and these other gut hormones, amylin, glucagon, GIP, that's what they're called that signal, for some reason, is not getting to the brain in ample amounts to tell the individual to feel full, satiated, and stop eating
