Based on preclinical (animal and cellular) data only, inhibition of NNMT by 5-Amino-1MQ is theorised to: Raise intracellular NAD+ levels Activate SIRT1 and other sirtuins (proteins linked to metabolic regulation) Reduce fat cell (adipocyte) size and proliferation Improve insulin sensitivity These effects have been demonstrated in mouse models (Neelakantan et al., 2019), but robust human clinical trial data are currently absent
Another reason to use the cyanocobalamin as opposed to the more expensive kinds is that it has a track record of safety and efficacy, whereas for example, in one study even up to 2,000 micrograms a day of methylcobalamin wasnt enough to correct vitamin B12 deficiency in one of three vegans they tested it on
Using too much causes excessive dilution and inaccurate doses, while too little makes small dose measurements difficult and increases error risk
This increases neurodegenerative conditions in the body leading to dementia and often times peripheral neuropathy
Research focuses on a disulfide bridge that locks the fragment into a rigid shape and on how it engages lipolytic signalling in fat cells
In fact, most people don't