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Substantial levels of progenitor cell emigration from the SVZ to demyelinated lesion sites are also consistently observed in MS models (Nait-Oumesmar et al., 1999
Both IFN- released by NKs and CD4 T cells upregulates HLA-II expression in adjacent cells (such as epithelial cells), which favors the acquisition of a nonprofessional antigen-presenting cell phenotype [199, 200]
Chronic use of these medications without concurrent glutathione support may contribute to long-term oxidative stress accumulation and cellular dysfunction
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