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The underlying driver is chronic inflammationspecifically, dysregulated immune signaling involving TNF-, interleukins (IL-17, IL-23), and NF-B pathways
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doi: 10.1016/j.ejphar.2015.09.029 67 PajaresMRojo AIMandaGBoscLCuadradoA
PEG is inert and highly hydrated, so it dramatically increases the molecule's effective size and shields it from proteases
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All seven peptides failed on multiple grounds
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