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GLP-1 receptor agonism glucose-dependent insulin secretion GIP receptor agonism additional insulinotropic and adipose signaling Glucagon receptor agonism hepatic energy expenditure and lipolysis Balanced tri-agonism energy expenditure alongside reduced energy intake Fatty-acid conjugation albumin binding and extended plasma half-life Core Areas of Scientific Investigation Multi-Receptor Agonist Design: it is studied as a model for balancing potency across three receptors within one peptide sequence without producing unopposed glucagon signaling

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