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Statements Author contributions AF, EDY and RS discussed the concepts and pitfalls, and wrote the manuscript

Biosynthesis and molecular structure of vitamin C In animals, biosynthesis of vitamin C is included in the glucuronic acid metabolic pathway, which is involved in the metabolism of sugars under normal and disease conditions, and in regulation of physiological functions (Figure 1a)

Despite the use of rodents and small mammals being commonplace in research, in particular for the development of novel therapeutic agents, caution still needs to be practiced when extrapolating research data to clinical applications

Duffus JH

10.1016/j.yexcr.2021.112932 131 XieY.SongX.SunX.HuangJ.ZhongM.LotzeM

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