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Footnotes Grants and fellowships This work was supported by funding from Fondation pour la Recherche Mdicale (quipe FRM EQU202203014629), and the Agence Nationale de la Recherche (grant ANR PRC 2023 CE14 GutStunting)

Standard cycle timing The most common recommendation is a 4-week active cycle followed by a 2-4 week rest period

When he went on the drug liraglutide, doctors noticed that his sleeping improved

Options your provider may consider include extending the time between dose increases to give your gut more time to adapt, temporarily reducing the dose until constipation management strategies take effect, or switching between GLP-1 medications if one produces intolerable side effects