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In cancer therapy, P-gp plays a crucial role in multidrug resistance (MDR) by actively pumping out chemotherapeutic agents, thereby reducing their intracellular concentration and leading to treatment failure (Fig

Indeed, G6PD-deficient monocytes exhibit decreased inflammasome responsiveness to LPS, including poor induction of pro-interleukin-1 (IL-1), which has been linked to insufficient NADPH oxidase production of ROS and impaired intracellular bacterial killing (18)

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These results suggest that TMPRSS2 plays an essential role in the elastase-mediated enhancement of infectivity of pseudotyped bat SARS-like CoVs