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For instance, in mouse embryonic stem cells, targeted disruption of glucose-6-phosphate dehydrogenase, which is the rate-limiting enzyme in the pentose phosphate pathway, the predominant metabolic pathway for the generation of NADPH (a cofactor of GR), renders cells extremely sensitive to H 2 O 2 -induced cell death 34
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Reduced levels of glutathione in these diseases may improve the sensitivity of cells to oxidative stress, thereby damaging cellular functions ( Generally, glutathione, serving as the major antioxidant inside cells, not only directly erasing free radicals but also remains oxidative balance within cells by various mechanisms, which is crucial for keeping cellular health
Inflammasomes are receptors/sensors of the innate immune system that regulate caspase-1 activation in response to host-derived proteins
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Unlike complete growth hormone therapy, AOD-9604 does not elevate IGF-1 levels or affect blood sugar regulation
