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There are estrogen receptors pretty much everywhere in the body from the brain and eyes to ligaments and tendons so when those tissues are supported with hormone therapy, women can experience less brain fog and hot flashes, and fewer aches and pains (less frozen shoulder!)

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For example, the RNA sequencing analysis on isolated enteroendocrine cells from obese individuals with or without T2DM revealed decreased expression of the PCSK1 gene in the jejunal epithelium, contributing to the biosynthesis of GLP-1 [32]

During chronic cold acclimation, KO mice maintained a higher RER than controls, indicating persistent reliance on carbohydrates

Why do high-fat fast foods cause discomfort on GLP-1 medications

Originally, GLP-1 agonists were used to treat type 2 diabetes