Neither drug is muscle-sparing on its own
Beyond common gastrointestinal side effects, the FDA has documented dosing errors with compounded injectable semaglutide leading to overdosing, and has raised concerns about products with certain salt forms (semaglutide sodium/acetate) and products from non-verified sellers
doi: 10.1038/s12276-023-01077-y 65 ZhaoW-BShengR
Andres Splenser, MD, an endocrinologist at Memorial Hermann, who was not involved in this study, suggested that the link may have something to do with the relationship between mood and appetite, among other potential factors
Remaining Scope for Side-Effect Improvement Retatrutide is a triple-action therapy that, like Lillys Mounjaro and Zepbound drugs, targets glucagon-like peptide-1, or GLP-1, and glucose-dependent insulinotropic polypeptide, or GIP, while also acting on the glucagon receptor
Targeting ATF4-DDIT4/TXNIP induced mitochondrial dysfunction and ferroptosis: ISRIB as novel therapy for septic cardiomyopathy