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In short, this article employs an automated systemic scanning the amino acids of the backbone of semaglutide as shown in Figure 1, where the semaglutide-GLP-1R complex structure (PDB ID: 4ZGM [29]), an in silico high-throughput generation [47] of structural and intermolecular binding affinity (K d ) data follows three criteria: position 8 (scissor in Figure 1) remains unchanged

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