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Whilst both are licensed for weight management in the UK, they differ significantly in how they work, administration routes, side effect profiles, clinical effectiveness, and NHS accessibility

Diagnosis of other severe psychiatric disorder (for example, schizophrenia, bipolar disorder)

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Lesions suspected of being malignant on dermatoscopy or those for which the nature cannot be clearly established, must be surgically excised with a narrow border [27]

35 Notably, this protective effect appears to be dependent on the duration of treatment, with only a GLP-1RA treatment period exceeding 52 weeks being associated with decreased fracture risk