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J Clin Invest 2021;131:e144201

Your prescriber may delay dose increases if gastrointestinal symptoms are troublesome

While results from IV ALA studies are consistently positive, the picture is more mixed when it comes to oral-only supplementation: A four-year randomized trial found no significant improvement in a composite measure of nerve function with 600mg/day of oral ALA compared to placebo

[] In a 15-year-old girl with unresponsive to treatment OCD, the addition of NAC (adjusted from 600 mg daily to 2.4 g/day for 6 weeks and continued for another 18 weeks at 2.4 g) to citalopram considerably reduced the severity of OCD symptoms, according to Yazici and Percinel (2014)

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1c and Extended Data Fig