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29 In terms of the nervous system, GLP-1 receptor (GLP-1R) expression is enriched in central nervous system (CNS) regions, including the hypothalamus, which regulates appetite, and the brainstem, which primarily secretes brain-derived GLP-1, as well as in the peripheral vagus nerve

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13,14 Recent findings support the multiple-hit hypothesis of the pathogenesis of NAFLD, which states that systemic changes such as liver, intestinal tract, and adipose tissue changes lead to the development of NAFLD

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