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These include the emergence of drug resistance, local toxic side effects of radiotherapy, and the associated risks related to surgery [11]

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It is the kind of reasoning that sounds plausible on paper and has not been put to a controlled test

Sex differences in hepatic one-carbon metabolism

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Moreover, ECM may influence OLs through regulation of tissue stiffness, which regulates OL differentiation 166 , and is increased in chronic demyelination yet decreased during remyelination 167