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This process increases flux into the non-oxidative branch of the pentose phosphate pathway (PPP) and further increases nucleotide biosynthesis and promotes tumor progression [278]
The primary antibodies used are as follows: P53 (Proteintech, 60283-2-Ig), pSer46-P53 (CST, 2521), FOXO4 (Proteintech, 21535-1-AP), Ki-67 (D3B5) Rabbit mAb (Alexa Fluor 647 Conjugate) (CST, 12075), P21 (CST, 14074), -H2AX (Abcam, ab2254)
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Additionally, agrimonolide significantly downregulates SCD1 expression in tumor tissues in SKOV-3 xenotransplantation models, reducing tumor growth of ovarian cancer
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