This is because berberine derivatives can cross the blood-brain barrier and target mitochondria in the meantime (Wang L
The hypothalamus, which is functionally integrated into the limbic system, is considered the main ANS control center (33)
To minimize any negative effects, simply opt for a lower dose
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(PubMed) Higashi Y, Noma K, Yoshizumi M, Kihara Y
Therefore, the disadvantages of hydroxychloroquine use outweigh its advantages, preventing its use for relieving EBV-acquired immunodeficiency and potentially worsening the condition of patients with LC or ME/CFS [410]