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These may include gastrointestinal issues like nausea, diarrhea, and vomiting
On the test day, 7 consecutive trials of 2 min per trial (with 1-min intertrial intervals) were undertaken with the following set speeds: 12, 16, 20, 25, 30, 35, and 40 rpm
The long half-life is driven by albumin binding (greater than 99% bound), reduced DPP-4 degradation due to the Aib8 substitution, and slowed renal clearance of the larger albumin-bound complex
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The identified literature was narratively synthesized without formal study selection protocols, risk-of-bias assessment, or quantitative meta-analysis
The renal clearance of alogliptin (9.6 L/hr) indicates some active renal tubular secretion and systemic clearance was 14.0 L/hr
